Internal Medicine

The Emperor of All Maladies is a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years.

The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist.

From the Persian Queen Atossa, whose Greek slave may have cut off her diseased breast, to the nineteenth-century recipients of primitive radiation and chemotherapy to Mukherjee’s own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through fiercely demanding regimens in order to survive—and to increase our understanding of this iconic disease.

Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

Neuroscientists once believed your brain was essentially "locked down" by adulthood. No new cells. No major changes. If you grew up depressed, angry, sad, aggressive, or nasty, you'd be that way for life. And, as you grew older, there'd be nowhere to go but down, as disease, age, or injury wiped out precious, irreplaceable brain cells. But over the past five, ten, twenty years, all that's changed. Using fMRI and PET scanning technology, neuroscientists can now look deep inside the human brain and they've discovered that it's amazingly flexible, resilient, and plastic. This book shows you what they've discovered and what it means to all of us. Through masterfully written narrative and stunning imagery, you'll watch human brains healing, growing, and adapting to challenges. You'll gain powerful new insights into the interplay between environment and genetics, begin understanding how people can influence their own intellectual abilities and emotional makeup, and understand the latest stunning discoveries about coma and "locked-in" syndrome. You'll learn about the tantalizing discoveries that may lead to cures for traumatic brain injury, stroke, emotional disorders, PTSD, drug addiction, chronic pain, maybe even Alzheimer's. Miriam Boleyn-Fitzgerald even shows how these discoveries are transforming our very understanding of the "self", from an essentially static entity to one that can learn and change throughout life and even master the art of happiness.

NAMED ONE OF THE TEN BEST BOOKS OF THE YEAR BY
Janet Maslin, The New York Times • People • Vogue
 
ONE OF THE BEST BOOKS OF THE YEAR
—Financial Times • Chicago Sun-Times
The Independent • Bookreporter
The Sunday Business Post

Mom loved adages, quotes, slogans. There were always little reminders pasted on the kitchen wall. For example, the word THINK. I found THINK thumbtacked on a bulletin board in her darkroom. I saw it Scotch-taped on a pencil box she’d collaged. I even found a pamphlet titled THINK on her bedside table. Mom liked to THINK.
 
So begins Diane Keaton’s unforgettable memoir about her mother and herself. In it you will meet the woman known to tens of millions as Annie Hall, but you will also meet, and fall in love with, her mother, the loving, complicated, always-thinking Dorothy Hall. To write about herself, Diane realized she had to write about her mother, too, and how their bond came to define both their lives. In a remarkable act of creation, Diane not only reveals herself to us, she also lets us meet in intimate detail her mother. Over the course of her life, Dorothy kept eighty-five journals—literally thousands of pages—in which she wrote about her marriage, her children, and, most probingly, herself. Dorothy also recorded memorable stories about Diane’s grandparents. Diane has sorted through these pages to paint an unflinching portrait of her mother—a woman restless with intellectual and creative energy, struggling to find an outlet for her talents—as well as her entire family, recounting a story that spans four generations and nearly a hundred years.
 
More than the autobiography of a legendary actress, Then Again is a book about a very American family with very American dreams. Diane will remind you of yourself, and her bonds with her family will remind you of your own relationships with those you love the most.